𝗚𝗲𝗻𝗲𝗿𝗶𝗰 𝗻𝗮𝗺𝗲: Fipronil
𝗕𝗿𝗮𝗻𝗱 𝗻𝗮𝗺𝗲: Frontprime for dogs (10 kg – 20 kg)
𝗗𝗼𝘀𝗮𝗴𝗲 𝗳𝗼𝗿𝗺: Spot-on tube
𝗗𝗼𝘀𝗮𝗴𝗲 𝘀𝘁𝗿𝗲𝗻𝗴𝘁𝗵: 100 mg/mL
𝗣𝗿𝗼𝗱𝘂𝗰𝘁 𝗽𝗿𝗲𝘀𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻: Box of 3’s

𝗔𝗖𝗧𝗜𝗩𝗘 𝗜𝗡𝗚𝗥𝗘𝗗𝗜𝗘𝗡𝗧
Fipronil …………………………… 100 mg

𝗣𝗛𝗔𝗥𝗠𝗔𝗖𝗘𝗨𝗧𝗜𝗖𝗔𝗟 𝗙𝗢𝗥𝗠
A colorless to pale yellow clear spot-on solution.

𝗣𝗛𝗔𝗥𝗠𝗔𝗖𝗢𝗟𝗢𝗚𝗜𝗖𝗔𝗟 𝗘𝗙𝗙𝗘𝗖𝗧𝗦
Pharmacology
The integration of fipronil and y-GABA receptor of central nerve cells in insects, blocks the chloride channel of nerve cells, thereby interfering the normal function of the central nerve, leading to death of insects and acarid due to super excitation of central nervous system.

Pharmacokinetics
A topical application of fipronil is distributed over the epidermis and binds to lipids in the hair follicles and sebaceous glands with minimal absorption. Over time, the drug is released from the epidermal reservoir to provide sustained activity. Fipronil could be systemically distributed and the metabolite of fipronil-sulfone, which excretes through the feces and urine with the remaining fipronil.

𝗜𝗡𝗗𝗜𝗖𝗔𝗧𝗜𝗢𝗡
For the treatment of flea (Ctenocephalides spp.), tick (Dermacentor reticulatus) infestations and biting lice (Trichodectes canis) infestations on dogs

𝗗𝗢𝗦𝗔𝗚𝗘 𝗔𝗡𝗗 𝗔𝗗𝗠𝗜𝗡𝗜𝗦𝗧𝗥𝗔𝗧𝗜𝗢𝗡
Only for external use. Hold the pipette in an upright position, twist and pull the cap off. Spread the animal hairs in the area between the shoulder blades to make the skin visible. Put the tip of the pipette onto the skin and press the unit-dose pipette several times to empty its contents directly onto the skin at one or two spots. Please use it monthly. Administer by topical application to the skin according to the body weight as follows:

𝗪𝗲𝗶𝗴𝗵𝘁 (𝗸𝗴) 𝗩𝗼𝗹𝘂𝗺𝗲 (𝗺𝗟) 𝗡𝘂𝗺𝗯𝗲𝗿 𝗼𝗳 𝘁𝘂𝗯𝗲𝘀 𝗽𝗲𝗿 𝗺𝗼𝗻𝘁𝗵
10-20 1.34mL 1

𝗔𝗗𝗩𝗘𝗥𝗦𝗘 𝗥𝗘𝗔𝗖𝗧𝗜𝗢𝗡𝗦
If licking occurs, a brief period of hypersalivation may be observed due mainly to the nature if the carrier. Among the extremely rare suspected adverse reactions, transient cutaneous reactions on the application site (skin discoloration, local alopecia, pruritus, erytherma) and general pruritus ir alopecia have been reported after use. Exceptionally, hypersalivation, reversible neurologic symptoms (hyperenthesua, depression, nervous symptoms), vomiting or respiratory symptoms have been observed after use. Once any of the above conditions occur, the treatment should not be continued.

𝗖𝗢𝗡𝗧𝗥𝗔𝗜𝗡𝗗𝗜𝗖𝗔𝗧𝗜𝗢𝗡𝗦
Developed only for external use of dogs. Do not use it in cats in case of overdosing.

Do not use on puppies less than 2 months old and/or weighing less than 2 kg in the absence of available data. Do not use it on sick (e.g., systemic diseases, fever) or convalescent animals.

Animals should be weighed accurately prior to treatment. Dogs should not be allowed to take bathe or swim in water courses for 2 days after application. After that, bathing too often is not recommended. (Once a week is most)

It is important to make sure that the product is applied to an area where the animal cannot lick it off